COMPARE-UF is a nationwide registry of women with uterine fibroids that hopes to answer questions about the outcomes of different treatment options.compare-uf_The-Registry

  • How do different treatments affect the ability to become pregnant, symptoms from uterine fibroids (such as bleeding and pain), and overall quality of life?
  • Are some treatment options better than others for different groups of women?

Each participant will make treatment decisions with her personal doctor, and then share information about her current and past experiences with her fibroids, including how fibroids have impacted her quality of her life.

View the COMPARE-UF Data Collection Summary to see the information that will be asked of participants and obtained from medical records.

The Duke Clinical Research Institute (DCRI) of the Duke University Medical Center in Durham, NC serves as the Research Data and Coordinating Center (RDCC). Dr. Evan Myers is the Principal Investigator of the COMPARE-UF Registry.

Learn more about the people and groups working to make COMPARE-UF a success.




Our aim is to understand which fibroid treatment options are most effective and what factors influence treatment outcomes.

We hope that the information we learn from this registry will help answer those questions so women with uterine fibroids will be able to make informed decisions about their treatment options.

How did we get here?

Uterine fibroid research interest by the Agency for Healthcare Research and Quality (AHRQ) has been ongoing since 1999.

1999-2000 Literature Review
2000–2005 Study of Uterine Artery Embolization
2007 Update to Literature Review
2010–2011 Priorities Set
2012 Application for Funding
2013 PCORI/Stakeholder Conference
2013–2014 Request for Application
2015 - Registry Enrollment Begins