FAQs

Frequently asked questions about participating in COMPARE-UF

What is the purpose of COMPARE-UF?
Our aim is to understand which treatment options are most effective and what factors influence treatment outcomes. Despite knowing much about fibroids, we don’t know how different treatment options compare to each other in terms of how well each relieves symptoms, how long the relief lasts, different complications or side effects, or how a treatment may affect a woman’s chance of having a healthy baby. We hope that the information we learn from this registry will help answer those questions so women with uterine fibroids will be able to make informed decisions about their treatment options.
Who can participate in COMPARE-UF?
Women between 18 and 54 years of age who have been diagnosed with fibroids using imaging (such as ultrasound or MRI), and are not in the transition to menopause (still having regular periods), and are scheduled to have a procedure to treat their fibroids at an enrolling site may be eligible.
We will follow 10,000 women at 9 or more centers, with many enrolling sites in the United States for ~3 years, and ask questions about the type of treatment they received, and the outcome of that treatment on their health and well-being.
Where can I enroll in COMPARE-UF?
View the site map to find the enrollment status and contact information for a center near you. Click on a state name below to see cities with enrolling centers.

California

Irvine – University of California, Irvine
Los Angeles – University of California, Los Angeles
Sacramento – University of California, Davis Medical Center
San Diego – University of California, San Diego
San Francisco – University of California, San Francisco

Hawaii

Honolulu — Tripler Army Medical Center

Maryland

Bethesda — Walter Reed Army Medical Center

Massachusetts

Boston — Brigham and Women’s Hospital; Massachusetts General Hospital

Maryland

Bethesda — Walter Reed National Military Medical Center; Uniformed Services University of the Health Sciences

Michigan

Ann Arbor — University of Michigan

Detroit — Henry Ford Medical Center New Center One; Henry Ford Medical Center  Detroit Northwest

Grosse Pointe Farms — Henry Ford Medical Center – Pierson

Hamtramck — Henry Ford Medical Center Hamtramck

Livonia — Henry Ford Medical Center

Royal Oak — Henry Ford Medical Center

Sterling Heights — Henry Ford Medical Center Lakeside

Taylor —Henry Ford Medical Center

Troy — Henry Ford Medical Center, Troy Reproductive Medicine

Minnesota

Eau Claire — Mayo Clinic Health System

LaCrosse — Mayo Clinic Health System

Mankato — Mayo Clinic Health System

Rochester — Mayo Clinic Health System

Mississippi

Flowood — University of Mississippi

Jackson — University of Mississippi

North Carolina

Cary — University of North Carolina Rex/UNC Family Practice of Panther Creek

Chapel Hill — University of North Carolina Women’s Hospital; University of North Carolina at Timberlyne

Hillsborough — University of North Carolina Hillsborough Campus

Raleigh — Rex Hospital

Virginia

Falls Church — Inova Health Systems

Washington

Tacoma — Madigan Army Medical Center

Wisconsin

Eau Claire — Mayo Clinic Health System in Eau Claire

LaCross — Mayo Clinic – Franciscan Healthcare

If I live in one of the enrolling cities but am not a patient of the clinic, may I participate?
Doctors have formal affiliations (‘privileges’) with hospitals, surgical centers, etc. Ask your doctor if they are affiliated with one of our enrollment centers. If they are, you can participate in the registry. If your doctor isn’t affiliated with an enrollment center, you would need to find a new doctor at one of those centers for your procedure. Although we hope that as many women as possible participate in the registry, switching your doctor just to participate is probably not going to be worth the effort for most women.

As COMPARE-UF expands, there may be new options available for women to participate; check this website to find out.

If a woman speaks only Spanish, may she participate in COMPARE-UF?
As part of our initial recruitment, women who participate must speak English. We hope to broaden our enrollment to native Spanish speakers in the future.
What will happen if I participate in this registry?
If you join the registry, we will ask you to sign a consent form, then answer questions about your medical and reproductive history, fibroid treatments and symptoms, and how you are feeling. We will also ask permission to gather information about your fibroid treatment from your medical record.
The study coordinating center at Duke University will contact you by telephone one, two, and three years after your procedure as part of the long-term follow-up, or you can complete the annual questionnaires online via a secure Internet portal. You may also have the option to participate in a second part of the study where women will give two blood samples, one before treatment and a second blood sample one year later.
What is a consent form?
If you are interested in participating in COMPARE-UF, we will ask you to sign a consent form. This form provides a detailed explanation of the purpose of COMPARE-UF and what we hope to learn. It also discusses what you will be asked to do as part of the registry, the risks and benefits of participating in COMPARE-UF, and any costs related to the project that you would be expected to pay.

The consent form also lets you know whom to contact for more information, and fully explains your rights in a clinical research registry, including

    • the right to confidentiality
    • the right to stop participating in the registry without penalty or loss of other medical care
What happens if I don't want to continue to participate?
You always have the right to stop participating. If you decide to stop participating, we will ask you to let us know by contacting the site at which you were enrolled or the Research Data and Coordinating Center at Duke University. There is more about this in the consent form.
This is a “Patient-centered Project.” What does this mean?

Patients are active partners with the researchers in COMPARE-UF.

Patients and patient organizations:

  • Helped identify the most important unanswered questions
  • Provided input on what information would be important to ask women with fibroids
  • Will help run the study by providing ongoing advice and input on all decisions about how to conduct the study
  • Will help spread the word about the study and what we hope to achieve in local and online communities
  • Will make sure that the results of the study get used by telling other patients about what we learn, and helping develop tools for making more informed decisions
How is the COMPARE-UF registry different from a clinical trial?
COMPARE-UF is a clinical research project called a registry, which means that we will just collect information about your medical history, your symptoms, details about your fibroids, and your treatment. PCORI (which is funding COMPARE-UF) defines a registry as “an organized system that uses observational study methods to collect uniform data (clinical and other) to evaluate specified outcomes for a population defined by a particular disease, condition or exposure, and that serves one or more predetermined scientific, clinical, or policy purposes.”
Unlike a clinical trial, there is no intervention (giving one drug or another, or providing different treatments for different groups of patients). COMPARE-UF is studying only procedures that are commonly used to treat fibroids. We are not studying “investigational” procedures. All treatment decisions are determined by you and your healthcare provider. We will only gather information about your treatment.
Who is funding this research?
How will my data be protected? Do you share my data?
We treat data very securely and we have no plans to share any data that might identify you as a participant.